Short duration transcranial direct current stimulation (tDCS) modulates verbal memory.

Javadi, A.-H., Cheng, P., Walsh, V.

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Transcranial direct current stimulation (tDCS) is a noninvasive method of modulating cortical excitability. The aim of this study was to investigate the effects of short-duration tDCS (1.6 seconds per trial) on memory performance, and whether the effects were affected by stimulation administered early or late in a trial. Participants memorise words under anodal and cathodal tDCS to the left dorsolateral prefrontal cortex (DLPFC) in two separate sessions in no-stimulation, early stimulation, and late stimulation trials. Early stimulation occurred during word presentation, whereas late stimulation occurred after word presentation. Early anodal tDCS led to significantly better accuracy and speed in a subsequent recognition test compared to anodal late or no-stimulation conditions. Early cathodal tDCS, on the other hand, led to significantly worse accuracy and speed in a subsequent recognition test compared with cathodal late or no-stimulation conditions. The results of this study suggest that short-duration tDCS can modulate memory performance and highlight the importance of period of stimulation.


1. Gandiga P, Hummel F, Cohen L. Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clin Neurophysiol 2006;117(4):845-850.

2. Paulus W. Transcranial direct current stimulation (tDCS). Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation, Gottinger, Germany; 2003. p. 249.

3. Nitsche M, Cohen L, Wassermann E, et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimul 2008;1(3):206-223.

4. Rosenkranz K, Nitsche M, Tergau F, Paulus W. Diminution of training induced transient motor cortex plasticity by weak transcranial direct current stimulation in the human. Neurosci Lett 2000;296(1):61-63.

5. Stone D, Tesche C. Transcranial direct current stimulation modulates shifts in global/local attention. Neuroreport 2009;20(12):1115.

6. Tanaka S, Hanakawa T, Honda M, Watanabe K. Enhancement of pinch force in the lower leg by anodal transcranial direct current stimulation. Exp Brain Res 2009;1-7.

7. Antal A, Nitsche M, Kincses T, Kruse W, Hoffmann K, Paulus W. Facilitation of visuo-motor learning by transcranial direct current stimulation of the motor and extrastriate visual areas in humans. EurJ Neurosci 2004;19(10):2888-2892.

8. Bolognini N, Pascual-Leone A, Fregni F. Using non-invasive brain stimulation to augment motor training-induced plasticity. J Neuroeng Rehabil 2009;6(1):8.

9. Hecht D, Walsh V, Lavidor M. Transcranial direct current stimulation facilitates decision making in a probabilistic guessing task. J Neurosci2010;30(12):4241.

10. Arul-Anandam A, Loo C. Transcranial direct current stimulation: a new tool for the treatment of depression? J Affect Disord 2009; 117(3):137-145.

11. Ferrucci R, Mameli F, Guidi I, et al. Transcranial direct current stimulation improves recognition memory in Alzheimer disease. Neurology 2008;71(7):493-498.

12. Schlaug G, Renga V. Transcranial direct current stimulation: a noninvasive tool to facilitate stroke recovery. Expert Rev Med Devices2008;5(6):759-768.

13. Miranda P, Lomarev M, Hallett M. Modeling the current distribution during transcranial direct current stimulation. Clin Neurophysiol2006;117(7):1623-1629.

14. Nitsche M, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 2000;527(3):633-639.

15. Galea JM, Jayaram G, Ajagbe L, Celnik P. Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. J Neurosci 2009;29(28):9115-9122.

16. Boggio P, Ferrucci R, Rigonatti S, et al. Effects of transcranial direct current stimulation on working memory in patients with Parkinson’sdisease. J Neurol Sci 2006;249(1):31-38.

17. Marshall L, Molle M, Hallschmid M, Born J. Transcranial direct current stimulation during sleep improves declarative memory. J Neurosci 2004;24:9985-9992.

18. Jo J, Kim Y, Ko M, Ohn S, Joen B, Lee K. Enhancing the working memory of stroke patients using tDCS. Am J Phys Med Rehabil2009;88(5):404. 6 Javadi, Cheng, and Walsh

19. Fregni F, Boggio P, Nitsche M, et al. Anodal transcranial direct currentstimulation of prefrontal cortex enhances working memory. Exp BrainRes 2005;166(1):23-30.

20. Ferrucci R, Marceglia S, Vergari M, et al. Cerebellar transcranial direct current stimulation impairs the practice-dependent proficiencyincrease in working memory. J Cogn Neurosci 2008;20(9): 1687-1697.

21. Fregni F, Boggio P, Nitsche M, Rigonatti S, Pascual-Leone A. Cognitive effects of repeated sessions of transcranial direct current stimulationin patients with depression. Depress Anxiety 2006;23(8):482-484.

22. Ohn S, Park C, Yoo W, et al. Time-dependent effect of transcranial direct current stimulation on the enhancement of working memory. Neuroreport 2008;19(1):43-47.

23. Iyer M, Mattu U, Grafman J, Lomarev M, Sato S, Wassermann E. Safety and cognitive effect of frontal DC brain polarization in healthyindividuals. Neurology 2005;64(5):872-875.

24. Elmer S, Burkard M, Renz B, Meyer M, Jancke L. Direct current induced short-term modulation of the left dorsolateral prefrontal cortex while learning auditory presented nouns. Behav Brain Funct2009;5:29.

25. Javadi AH, Walsh V. Transcranial direct current stimulation applied over left dorsolateral prefrontal cortex modulates declarative verbal memory. Brain Stimul (in press).

26. Im C, Jung H, Choi J, Lee S, Jung K. Determination of optimal electrode positions for transcranial direct current stimulation (tDCS).  Physics Med Biol 2008;53(11):219-225.

27. Antal A, Nitsche M, Kruse W, Kincses T, Hoffmann K, Paulus W.  Direct current stimulation over V5 enhances visuomotor coordination by improving motion perception in humans. J Cogn Neurosci 2004;  16(4):521-527.

28. Boggio P, Castro L, Savagim E, et al. Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation.  Neurosci Lett 2006;404(1-2):232-236.

29. Fl€oel A, R€osser N, Michka O, Knecht S, Breitenstein C. Noninvasive brain stimulation improves language learning. J Cogn Neurosci 2008;  20(8):1415-1422.

30. Kincses T, Antal A, Nitsche M, Bartfai O, Paulus W. Facilitation of probabilistic classification learning by transcranial direct current stimulation of the prefrontal cortex in the human. Neuropsychologia 2004;  42(1):113-117.

31. Lang N, Nitsche M, Sommer M, Tergau F, Paulus W. Modulation of motor consolidation by external DC stimulation. Suppl Clin Neurophysiol 2003;56:277-281.

32. Coltheart M. The MRC psycholinguistic database. Q J Exp Psychol 1981;33(4):497-505.

33. Brainard D. The psychophysics toolbox. Spatial Vision 1997;10(4):  433-436.

34. Pelli D. The VideoToolbox software for visual psychophysics: transforming numbers into movies. Spatial Vision 1997;10(4):437-442.

35. Cabeza R, Nyberg L. Imaging cognition II: an empirical review of 275 PET and fMRI studies. J Cogn Neurosci 2000;12(1):1-47.

36. Martin A. Functional neuroimaging of semantic memory. Handbook of Functional Neuroimaging of Cognition. Cambridge (MA): MIT Press; 2001. p. 153-186.

37. Cabeza R, Nyberg L. Neural bases of learning and memory: functional neuroimaging evidence. Curr Opin Neurol 2000;13(4):415.

38. Homan R, Herman J, Purdy P. Cerebral location of international 10-20 system electrode placement. Electroencephalogr Clin Neurophysiol 1987;66(4):376.

39. Poreisz C, Boros K, Antal A, Paulus W. Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients.  Brain Res Bull 2007;72(4-6):208-214.

40. Wagner T, Fregni F, Fecteau S, Grodzinsky A, Zahn M, PascualLeone A. Transcranial direct current stimulation: a computer-based human model study. Neuroimage 2007;35(3):1113-1124.

41. Cerruti C, Schlaug G. Anodal transcranial direct current stimulation of the prefrontal cortex enhances complex verbal associative thought.  J Cogn Neurosci 2008;21(10):1980-1987.

42. Hummel FC, Cohen LG. Drivers of brain plasticity. Curr Opin Neurol 2005;18:667-674.

43. Dockery C, Hueckel-Weng R, Birbaumer N, Plewnia C. Enhancement of planning ability by transcranial direct current stimulation.  J Neurosci 2009;29(22):7271-7277.

44. Nitsche M, Roth A, Kuo M, et al. Timing-dependent modulation of associative plasticity by general network excitability in the human motor cortex. J Neurosci 2007;27(14):3807.

45. Nitsche M, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 2001;57(10):1899-1901.

46. Nitsche M, Liebetanz D, Antal A, Lang N, Tergau F, Paulus W. Modulation of cortical excitability by weak direct current stimulationtechnical,  safety and functional aspects. Suppl Clin Neurophysiol 2003;56:255-276.

47. Nitsche M, Schauenburg A, Lang N, et al. Facilitation of implicit motor learning by weak transcranial direct current stimulation of the primary motor cortex in the human. J Cogn Neurosci 2003;15(4):619-626.